Check out these Home Remedies For Bed Bugs With Vinegar. The small, reddish-brown parasites known as bed bugs can trigger nightmares for homeowners because they feed on human blood. Although some natural therapies can be costly and complicated, they are effective against bed bugs. Use of vinegar is one method to address this. A common item in the kitchen, vinegar can be used for both cleaning and cooking. Upon encountering it, insects may be killed or have their reproductive cycles disrupted by its potent acidic qualities.