YES. Comcast customers are provided with a standard gateway device that serves as both a modem and a router. The Orbi system does work with these devices. To connect the systems, you need to turn off both devices and connect the Orbi to the Comcast modem. Log into the Orbi menu and set AP mode through the advanced setup menu. You can then reboot the Orbi and allow the Comcast device to assign an IP address to the Orbi. Moreover, the CBK40 model can replace the cable modem provided by Comcast thus connecting directly to the ISP (cost savings).